ABSTRACT
Objective To investigate the effect of Zhutan Tongluo Tang on the articular cartilage degeneration in a rat osteoar-thritis model ,and explore the potential mechanism .Methods Thirty-healthy SD rats were equally divided into the normal control group ,the model control group and Zhutan Tongluo Tang group .Rats were induced osteoarthritis models with 4% mass fraction of papain .After replication of osteoarthritis models ,Zhutan Tongluo Tang group were given Zhutan Tongluo Tang with 2 mL/(kg · d) ,the model control group were given lavage with normal saline ,the normal control group with rovtine feeding .After treat-ments for 3 months ,the cartilage morphology were observed using HE stains ,and the expression of IL-1β,TNF-α and MMP-3 in synovial fluid were measured by ELISA .Results The degeneration of cartilage in Zhutan Tongluo Tang group was better than the model control group .Compared with the model control group ,the expression levels of IL-1β (12 .13 pg/mL vs .16 .62 pg/mL ) , TNF-α (13 .76 pg/mL vs .18 .26 pg/mL) and MMP-3 (14 .21 ng/mL vs .21 .57 ng/mL) in synovial fluid were significantly de-creased in Zhutan Tongluo Tang group(P<0 .05) .Conclusion Zhutan Tongluo Tang has the function of treating delaying osteoar-thritis cartilage degeneration and decreasing inflammation ,whose mechanism is related to inhibiting the expression of inflammatory cytokines .
ABSTRACT
Objective To investigate the effect of Zhutan Tongluo Tang on the articular cartilage degeneration in a rat osteoar-thritis model ,and explore the potential mechanism .Methods Thirty-healthy SD rats were equally divided into the normal control group ,the model control group and Zhutan Tongluo Tang group .Rats were induced osteoarthritis models with 4% mass fraction of papain .After replication of osteoarthritis models ,Zhutan Tongluo Tang group were given Zhutan Tongluo Tang with 2 mL/(kg · d) ,the model control group were given lavage with normal saline ,the normal control group with rovtine feeding .After treat-ments for 3 months ,the cartilage morphology were observed using HE stains ,and the expression of IL-1β,TNF-α and MMP-3 in synovial fluid were measured by ELISA .Results The degeneration of cartilage in Zhutan Tongluo Tang group was better than the model control group .Compared with the model control group ,the expression levels of IL-1β (12 .13 pg/mL vs .16 .62 pg/mL ) , TNF-α (13 .76 pg/mL vs .18 .26 pg/mL) and MMP-3 (14 .21 ng/mL vs .21 .57 ng/mL) in synovial fluid were significantly de-creased in Zhutan Tongluo Tang group(P<0 .05) .Conclusion Zhutan Tongluo Tang has the function of treating delaying osteoar-thritis cartilage degeneration and decreasing inflammation ,whose mechanism is related to inhibiting the expression of inflammatory cytokines .
ABSTRACT
Objective To study the efficacy of treatment of proximal humeral fractures in elderly patients using cloverleaf plate combined with bone cement. Methods 13 aged patients with serious proximal humeral fractures were admitted from 2000.1 to 2001.6. Their X ray revealed displacement and crispation. After anterior reduction through the shoulder joint, the obvious osseous defects were filled with bone cement. Then the fractures were fixed with cloverleaf plates. Sling was applied for the patients postoperatively and the rehabilitation program started 3 weeks after operation. Results All the 13 cases were followed up. The follow up ranged from 5 to 10 months with an average of 8.3 months. The range of motion was satisfactory with a mean abduction over 90 degrees. X ray revealedthat no patient demonstrated osteonecrosis of the humeral head. Union was achieved in all the patients. According to Neers scale, the function of shouder was excellent in 10 cases, and good in 3 cases. Conclusion This methods is recommended for aged patients with osteoporosis, serious osseous defects and difficulty of using internal fixation alone, because it is convenient and reliable and can prevent replacement of joint prosthesis.
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Objective To investigate the effectiveness of arthroscopic reduction and percutaneous fixation (ARPF) for the treatment of tibial plateau fractures. Methods Seventeen cases of tibial plateau fractures from April 1999 to June 2002 were reviewed. The fractured tibial plateau was reconstructed by “drag-and-draw” reduction and iliac crest bone graft under arthroscope. And percutaneous cancellous bone screw fixation was conducted. Results Clinical bone union was achieved in all the patients at the third postoperative month. No infection or severe osteoarthritis occurred. Conclusions ARPF for tibial plateau fractures has advantages of reduction under direct view, reliable fixation and facilitation for early activities.